– What is the coagulation cascade
– What is its biological function
– How does it work (contact and TF pathway*, pro and anticoagulant pathways)
– What tests can you use to assess coagulation (PT, APTT, thrombin generation)
– What do these tests measure and what do changes in the tests indicate**
* Intrinsic and extrinsic are old terminology (use contact and TF pathway)
** Indicate that shortened clotting times/increased thrombin generation are pro coagulant and may be associated with thrombosis while prolonged clotting times/decreased thrombin generation may be associated with bleeding.
At the end of this section, you should have a line that links coagulation to pregnancy.
For Example…..(just can use this one)
Beyond its critical role in haemostasis, the coagulation cascade has been shown to play an important role in many physiological and pathological processes. These include pregnancy and pregnancy related disorders such as preeclampsia.
2- Early onset vs late Onset Preeclampsia:
-what’s the difference
3- Coagulation in Preeclampsia:
– Is preeclampsia associated with an increase in VTE (how much is the risk increased compared to normal pregnancy and non pregnant individuals)
– Is coagulation altered in vivo and in vitro
– are there changes in parameters of coagulation (coagulation factor levels change, D-Dimer levels, changes in clotting times, thrombin generation). How much do they change.
– Do women with thrombophilia have an increased risk of preeclampsia.
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